The first full week of the 2026-27 season has been rough on the league's best players. Anthony Edwards, Jalen Williams, Jaren Jackson Jr. and Kawhi Leonard are among the names now facing weeks or months out, and Wednesday's 12-game slate is the first one shaped by all of it. So before the cards, the first edition of our weekly injury ledger, split by how long each player is expected to be out. Then Philadelphia visits an Indiana team waiting on Tyrese Haliburton's hamstring, Golden State visits a Minnesota team waiting on Edwards's knee, and an Oklahoma City team missing six players brings its 4-0 start to Dallas. Those three are free; the other nine cards are in Tome Intel. All times are Eastern.

Philadelphia 76ers @ Indiana Pacers | 7:00 PM ET | ESPN

Philadelphia is 3-1 and coming off its first loss, 106-93 at home to Detroit on Sunday with Joel Embiid resting the second night of a back-to-back. Tyrese Maxey scored 29 in that game and LeBron James 18. Embiid is not on Wednesday's report, and the 76ers have had two days off. Ariel Hukporti, Dominick Barlow, Tacko Fall and Jabari Walker remain out.

Indiana's injury list is the story. Tyrese Haliburton, a week into his return from the Achilles tear, is questionable with left hamstring tightness after scoring 22 with nine assists in Monday's loss in Milwaukee. Ivica Zubac is out with a left ankle sprain, T.J. McConnell and Ben Sheppard are out, and Andrew Nembhard is questionable with neck stiffness. Pascal Siakam had 20 points and 13 rebounds on Monday.

Without Zubac, Indiana has little size to throw at Embiid, and if Haliburton sits, the Pacers' offense runs through Siakam and Nembhard. The market has already priced some of that.

Philadelphia wins if Embiid takes advantage of a frontcourt without Zubac, Maxey keeps up his pace, and the 76ers' rest shows in the second half.

Indiana wins if Haliburton is cleared, Siakam controls the glass, and the Pacers force Philadelphia's thin bench into heavy minutes.

Lean Indiana +4.5 (Strong), and lean the under 237.5 (Strong).

Golden State Warriors @ Minnesota Timberwolves | 8:00 PM ET | NBA League Pass

Minnesota's season changed in a day. Anthony Edwards scored 47 in Monday's two-point loss in Cleveland, and on Tuesday ESPN's Shams Charania reported that he will undergo arthroscopic surgery on his right knee and could miss up to two months. The official report still lists him as questionable for Wednesday with right knee injury management, so his status is the first thing to confirm. Donte DiVincenzo remains out after Achilles surgery.

Golden State finally won on Monday, 134-114 in Denver, and Stephen Curry was perfect: 24 points on 8-of-8 shooting. Yaxel Lendeborg added 31 points and 12 rebounds, but he is questionable with left foot soreness. Jimmy Butler, Moses Moody and Kristaps Porziņģis are out.

If Edwards sits, the Wolves turn to LaMelo Ball and Jaden McDaniels to carry the offense, with Rudy Gobert anchoring the defense. The book has already come three points toward Golden State, from Minnesota -6.5 to -3.5, which says the market expects him to be out.

Golden State wins if Curry stays hot, Lendeborg is able to go on the sore foot, and the Warriors' ball movement finds open shooters against a Wolves defense without Edwards.

Minnesota wins if Ball carries the offense, Gobert wins the paint, and the Wolves' depth holds up in the first game of what could be a long stretch without their star.

Lean Minnesota -3.5 (Strong), and lean the over 228.5 (Lean).

Oklahoma City Thunder @ Dallas Mavericks | 9:30 PM ET | ESPN

Oklahoma City keeps winning while the injury report keeps growing. The Thunder beat Phoenix 125-114 on Monday with Ajay Mitchell scoring 30 and Shai Gilgeous-Alexander 26, a day after Jalen Williams (dislocated ankle, fractured fibula) and Cason Wallace (torn labrum) were hurt against the Clippers. Now Chet Holmgren (knee tendinitis) and Alex Caruso (ankle) are out too, and Mitchell is questionable with an ankle sprain.

Dallas is 2-2 and has its star back. Cooper Flagg returned from his shoulder sprain on Monday with 29 points and 11 assists in a 113-109 win in Miami, and P.J. Washington added 20. Kyrie Irving is questionable with knee management, Dereck Lively II and Sergio de Larrea are out, and Santi Aldama and Tarik Biberovic are doubtful.

This is the most short-handed game on the slate for both sides. The matchup that's left is Gilgeous-Alexander against Flagg's Mavericks defense, with Isaiah Hartenstein anchoring the Thunder frontcourt alone.

Oklahoma City wins if Gilgeous-Alexander takes over, Mitchell is cleared and keeps scoring, and Hartenstein holds up as the only big in the rotation.

Dallas wins if Flagg builds on Monday, Irving is cleared, and the Mavericks use their healthier rotation against a Thunder team with six players out.

Lean Dallas +5.5 (Lean), and lean the under 229.5 (Lean).

Watch Haliburton's and Edwards's statuses before the 7:00 and 8:00 games, how a six-man-short Thunder team holds up in Dallas, and whether Dybantsa debuts in Cleveland. Several of tonight's widest gaps come from injuries our number can't see, and those cards say so. That's 12 cards on the side and 12 on the total, three free and nine in Tome Intel. We'll have the recap Thursday with every card graded.